Ana counters, tier and perks

Hero Playbooks tier: B (confidence low). Matchup data confidence: high. Last updated 2026-10-14.

Abilities

Biotic Rifle · Sleep Dart · Biotic Grenade · Nano Boost

Genji: Ana struggles with Genji's pressure up close. (high confidence)
Anran: Anran is mobile enough to avoid Ana's Sleep Dart and Biotic Grenade. (high confidence)
Wuyang: With little mobility and modest poke, Ana usually trades poorly against Wuyang at long range. (high confidence)
Lifeweaver: Life Grip rescues allies hit by Sleep Dart or Biotic Grenade, undoing both of Ana's key cooldowns. (high confidence)
Zarya: If Biotic Grenade hits Zarya, she can remove the anti-heal by putting up her barrier afterward. (high confidence)
Sigma: Kinetic Grasp and Experimental Barrier let Sigma cancel Ana's abilities while he pressures her with his primary fire. (high confidence)

Wrecking Ball: If Ana times Sleep Dart or Biotic Grenade with his Piledriver, she can threaten to kill Wrecking Ball. (high confidence)
Domina: Stat-based: favored in Counterwatch duel data (rating +8.5); also favored by Overpicker counter matrix. No written explanation in our sources yet. (medium confidence)
Roadhog: Biotic Grenade's anti-heal cancels out the self-healing Roadhog gets from Take a Breather. (medium confidence)
Ramattra: Sleep Dart or Biotic Grenade lets Ana get the upper hand on Ramattra while he's in Nemesis Form. (medium confidence)
Torbjörn: Stat-based: team pressure in Counterwatch duel data (rating +4.6); also favored by Overpicker counter matrix. No written explanation in our sources yet. (medium confidence)
Symmetra: Stat-based: favored in Counterwatch duel data (rating +4.5); also favored by Overpicker counter matrix. No written explanation in our sources yet. (medium confidence)

Local Anesthetic: A Sleep Dart hit now explodes instead, slowing targets around it and burning 45 damage into them across 3 seconds.
Speed Serum: Using Nano Boost makes both Ana and the boosted ally move 30% faster.

Biotic Bounce: Biotic Grenade bounces after its first explosion and goes off a second time, dealing and healing 60.
Headhunter: Ana's Biotic Rifle shots can land critical hits on enemies.